Prof. Nikolay Dokholyan
Prof. Nikolay Dokholyan
USA
Center for Translational Systems Research Penn State College of Medicine
G. Thomas Passananti Professor Vice Chair for Research Department of Pharmacology Department of Biochemistry & Molecular Biology Director
Dr. Dokholyan received his PhD in Physics in 1999 at Boston University and completed the postdoctoral training at Harvard University in the Department of Chemistry and Chemical Biology as an NIH NRSA Fellow.

Dr. Dokholyan joined the Department of Biochemistry and Biophysics at the University of North Carolina at Chapel Hill School of Medicine as an Assistant Professor in 2002 and was promoted to Full Professor in 2011. Dr. Dokholyan has served as the Director of the Center for Computational and Systems Biology and the Graduate Director of the Program in Molecular and Cellular Biophysics at UNC. Dr. Dokholyan has published over 230 peer-reviewed articles and 20 chapters in books. In 2014, Dr. Dokholyan was named the Michael Hooker Distinguished Professor. In 2018, he assumed the position of the G. Thomas Passananti Professor and Vice Chair for Research in the Department of Pharmacology and the Director of the Center for Translational Systems Research, a position at the Penn State University Hershey Medical Center.


Topic & Abstract

Molecular Design for Research and Therapeutics

Life of biological molecules spans time and length scales relevant at atomic to cellular time and length scales. Hence, novel molecular modeling approaches are required to be inherently multiscale. Here we describe multiple methodologies developed in our laboratory: rapid discrete molecular dynamics simulation algorithm, protein design and structural refinement tools. Using these methodologies, we describe several applications that shed light on the molecular etiology of cystic fibrosis and finding new pharmaceutical strategies to combat this disease, model 3D RNA structure, and design novel approaches for controlling proteins in living cells and organisms.

EVENTS IN YOUR AGENDA: 0