After his postdoctoral research at Broad Institute, Dr. Myers became a Research Scientist in the Proteomics Platform and the Klarman Cell Observatory. Dr. Myers' research is focused on understanding how cells interpret their environment and integrate multiple signals to enact the appropriate response.

Cells in the body exist in dynamic environments. Upon normal or threatening changes, cells must process the new information and adapt rapidly and accordingly. As cells cannot directly measure everything, cells infer their surroundings largely through receptors in the cell membrane. When bound by their cognate ligand, the receptor transduces the signal across the membrane where thousands of biochemical reactions cascade to the nucleus to activate gene transcriptional programs via protein congregation to initiate the proper cellular response. While key events about many of these “signaling to transcription” pathways have been well studied tens of thousands of signal processing reactions are overlooked. Here, we will discuss the development of novel experimental and computational tools and approaches to better understand how cells “think” using these vast number of biochemical reactions, and how the “decisions” are made, i.e. activating or repressing specific gene expression. A better, more holistic understanding of information processing done by cells will allow us to better control gene expression by understanding which pathway(s) can be exploited for therapeutic purposes.